First Southern Bank Address: 1321 Highway 43 N, Picayune, MS 39466 Phone: (601) 798-6438 Banks Other Businesses: First National Bank at 208 W Canal St, Picayune, MS 39466 Hancock Bank at 2400 Highway 11 N, Picayune, MS 39466 First National Bank at 1721 Cooper Rd, Picayune, MS 39466 BankPlus at 115 Williams Ave, Picayune, MS 39466